OBJECTIVES: EQ-5D is a widely used generic health measure. One concern is the comparability of EQ5D derived weights of selected health states among different countries. Our objective was to estimate and compare EQ-5D health states’ weights for pneumoccocal and human papillomavirus (HPV) diseases in three different countries (Argentina, Chile and United Kingdom (UK). METHODS: Twelve health state vignettes (8 pneumococcal, 4 HPV) were designed and administered to a convenience sample in order to obtain descriptive data regarding the different disease-related EQ-5D health states. Subsequently, country specific EQ-5D time-trade off-based weights were used in order to map descriptive health states into local preference weights. Finally, inter-country differences for each condition were compared using repeated measures ANOVA. RESULTS: Between July and August 2009, 73 subjects (mean age = 31 years, range 22 to 58) successfully responded the questionnaire. Fifty-three percent of the respondents were female and 96% worked or studied in the health sector. For pneumoccocal disease-related health states, utility coefficients’ means ranged from -0.331 (sepsis, Chile) to 0.727 (auditive sequelae, Argentina). Regarding HPV-related conditions, their mean ranged from 0.152 (cervical cancer, United Kingdom) to 0.848 (CIN1, Argentina). Chile consistently showed the lowest values in pneumococcal states and in one HPV state, while those of UK were the lowest in most HPV states. Argentina showed the highest values in both disease groups. Mean differences between countries in pneumococcal health states were 0.256 (Argentina-Chile), 0.207(Argentina-UK), and 0.048(Chile-UK); and those for HPV were 0.117 (Argentina-Chile), 0.133 (Argentina-UK), and 0.017(Chile-UK). Differences in country-specific values for each health state were statistically significant (p<0.001). CONCLUSIONS: Preference weights for each condition differed significantly between analyzed countries even though the same health states´ mix was valued for each. These results stress the importance of using local and not international weights in context-specific decision making processes.