OBJECTIVES: To examine patients' preferences and satisfaction on completing Patient Reported Outcome (PRO) assessments in studies that compared paper-administered to electronic versions. To identify which data collection method patients prefer. To explore aspects that makes the PRO experience more positive or negative for patients. METHODS: A large literature search was conducted to gather articles that utilized ePRO. From that, articles were identified and reviewed that compared paper to ePRO and assessed for patient satisfaction/preferences. RESULTS: 119 articles were identified that utilized ePRO; 26 (21.8%) compared paper to ePRO. Of the 26, 17 (65.4%) reported on patient satisfaction/preferences. Electronic modalities consisted of handheld devices (70.6%), interactive voice response system (IVRS) (phone) (17.6 %), electronic data capture system (5.9%) and both IVRS and handheld (5.9%). Patient satisfaction/preference was assessed through either interviews (41.2%) or questionnaires (58.8%). Patients reported preferring ePRO over paper in 88.2% of the articles. Positives aspects of paper included: familiarity, not dependent on technology that may malfunction and ease of reading. Negative aspects of paper included: forgetting to complete and burden. Positive aspects of ePRO included: liked the diary's appearance, convenient, ease of data entry, fast/efficient, saves trees, reminders, overall survey experience, more fun/novel, easier on eye, more up-to-date, and comfort in handling. Negative aspects of ePRO included: system problems/failures, difficulty to read, difficult to use, instructions could have been simpler, and inability to change reminder time or enter data late. CONCLUSIONS: As PRO are measures that come directly from the patients, it is important to identify their preferences and aspects of what makes their experiences more positive. These findings suggest that patients overall preferred ePRO and identified more positive aspects for ePRO. Both positive and negative aspects reported are equally valuable in identifying how PRO data collection can be improved to provide patients with the most positive experiences.