OBJECTIVES: The Huntington Clinical Self-Reported Instrument (H-CSRI) is the first subjective clinimetric scale for patients with Huntington’s disease (HD). Such an instrument offers the advantage of allowing a remote follow-up, and collection of information on the development of motor, functional and behavioural symptoms of HD, perceived by the patients themselves. The objective of this study was to adapt and cross-culturally validate the H-CSRI for Spain. METHODS: The original questionnaire included three subscales assessing patients’ motor ability (13 Likert-type items in four dimensions), functional capacity (seven Yes/No questions) and behavioural ability (13 Likert-type items in four dimensions). The instrument was translated forwards and backwards by native speakers. The hospital ‘Hospital Ramon y Cajal’ provided their patients with the questionnaire. Classical test theory and item response theory were used to assess its clinimetric properties. Cross-cultural validation was assessed by differential item functioning analysis (DIF). RESULTS: A total of 59 patients filled in the H-CSRI questionnaire. The H-CSRI showed satisfactory psychometric proprieties. Item response rates ranged from 84% to 94%. A floor effect was found for five items in the behavioural dimension. The H-CSRI showed an acceptable reliability, as Cronbach’s alpha coefficients were higher than 0.85. Factor analyses demonstrated that the data were structured in the same way as for the French and the Italian versions. Item internal consistency (IIC) and item discriminant validity criteria were met for most items (i.e. IIC was > 0.40, and correlations between items and their respective rest-scores in one dimension were all greater than correlations with another dimension). The DIF analyses showed no item bias versus the Italian or French versions. CONCLUSIONS: The Spanish version of the H-CSRI showed acceptable clinimetric properties. This study supports the usefulness of the H-CSRI questionnaire to assess the clinical status of patients, although it is limited by the small sample size.