OBJECTIVES: To explore opinions among professionals in health economics and related fields on global trends in the use of health economic (HE) data in various market access decision-making processes. METHODS: An on-line survey was administered to professionals who work with HE data.  The survey captured professional background characteristics and respondents’ opinions on trends in the role of HE data in various decision-making areas and specifically in applying HE analysis to individualized medicine and orphan medications. RESULTS: Seventy three professionals completed the survey; 53% from Europe, 30% United States, and 16% from other countries. 25% were from the pharmaceutical/medical technology industry, while 75% were from academia/government and other institution types. The area where most respondents expected an increasing role for HE data was in reimbursement decisions (89%), followed by manufacturers’ internal pricing (78%), clinical guideline development (70%), and clinical practice (59%). Opinions on whether cost-effectiveness analysis of individualized medicine will become a dominant approach in the next three years varied widely with 49% of respondents in agreement and 19% disagreeing. Equally, 37% of the respondents agree and 37% disagree that orphan drugs should be subjected to the same value-based assessments as other products, with 26% being neutral. CONCLUSIONS: While there is strong agreement that the role of HE data will increase in the areas of pricing, reimbursement, clinical guideline development and clinical practice, there remains some disagreement about how specific HE approaches and policies will be applied in the near future. Further research is warranted to better understand the use of HE data in market access decision making globally.