Primary immunodeficiency (PI) constitutes a group of disorders involving a primary defect in the immune system often requiring lifelong Immunoglobulin (IG) therapy which can be administered intravenously (IGIV) or subcutaneously (IGSC).  OBJECTIVES: To quantify patient and caregivers preferences for administration attributes of IG treatments. METHODS: Adult patients and caregivers of children with PI from 21 non-U.S. countries recruited via national member organisations completed a web-enabled, choice-format survey. The conjoint analysis quantified the preferences of attributes presented to the respondents. The preference weights for each sample were scaled between 0 and 10. The vertical distance between adjacent preference weights indicated the relative importance of moving from one level of an attribute to an adjacent level of that attribute. RESULTS: A total of 216 patients and 84 caregivers completed the survey.  Patients and caregivers significantly preferred monthly to weekly, home setting to doctor’s office/hospital/ clinic, shorter duration, and fewer needle sticks of IG treatment (P <0.05). There was a difference in the ranking of these attributes between IGIV and IGSC users. IGIV users indicated frequency as the most important attribute followed by number of needle sticks, duration and home setting while IGSC users indicated home setting as the most important attribute followed by duration, self administration, number of needle sticks, and frequency. CONCLUSIONS: IG treatments that provide the comprehensive option of a monthly frequency, home setting, shorter duration, and fewer needle sticks may address the needs of both PI patients and caregivers, although ranking of these attributes may be different between the IGIV and IGSC users.