OBJECTIVES: This study explored the pattern and cost of medicines prescribed at a diabetic clinic in Ho Municipal Hospital, Volta Region, Ghana. METHODS: Cross sectional in design. A retrospective sampling procedure was used to collect data. 100 computer generated prescriptions were randomly selected from the computer data base for all OPD cases visiting the diabetic clinic in Ho Municipal Hospital between the periods of January 1 to December 31, 2011. With the aid of Excel and SPSS (vers 20), the data generated was analyzed and appropriate measures of centrality and percentages determined.  RESULTS: The data reveal a 100% written diagnosis for all prescriptions encountered. There were more females than males (70% vs 30%). The average number of drugs per prescription was 6.0. About 61% of the diabetic patients were also diagnosed with hypertension. Biguanides (95%) were the commonest oral hypoglycaemic agent prescribed while calcium channel antagonist (60%) was the commonest antihypertensive prescribed. The average cost of medication per prescription was GHC 40.0 (Ghana cedi) – approx $20.5 (USD), were as the average total cost of drugs per patient for the entire year was GHC 235.2 (Ghana cedi) – approx $120 (USD) CONCLUSIONS: The study demonstrates that most patients attending the diabetic clinic in Ho Municipal Hospital are females. The cost of diabetic medications to patient per prescription was expectedly high, particularly due to the high number of drugs prescribed. Most diabetic patients have hypertension. The prescription of ACE-I therefore need to be improved to reduce the rate of cardiovascular complication in diabetes.