OBJECTIVES: To investigate the effect of Epidermal Growth Factor (EGF) plus silver sulfadiazine (SSD) cream for treatment of burn wound. METHODS: The 34 patients who have partial thickness burn wounds and admitted at Burn Unit, Siriraj hospital during December 2011 to April 2012 were randomly divided into 2 groups receiving the topical treatment either 6% EGF plus 1% SSD cream group (study group) or 1% silver zinc sulfadiazine cream (control group). The study end point was the time of completely wound closure. Area of wound measurement and wound dressing was done every day. Percentage of epithelialization, pain and itching score, pain and itch medication used and chemistry laboratory results were evaluated every week until completely wound closure by epithelialization. RESULTS: The demographic data of both groups was similar with regards to sex, age, weight, social history, vital sign and wound characteristics. From this study, we found that the study group had significantly shorter healing time than of the control group. The study group also had higher percentage of epithelialization at every time points (p<0.05). However, there was no significant difference in percentage of wound contraction between both groups (p>0.05). Pain score and doses of pain-relieved medication used (paracetamol and morphine) in study group was significantly lower than in the control group. There was no difference in itching evaluation and itch-relieved medication used and blood chemistry parameters (p>0.05). The cost of treatment was similar in both groups even length of stay in study group was less compared to control group. CONCLUSIONS: Topical EGF plus silver sulfadiazine enhances wound healing in partial thickness burn wounds by reduced time of wound closure without any serious side effects. EGF application may be a new option for burn wound care in the future.