THE ECONOMIC BURDEN OF POST-TRANSPLANT EVENTS IN RENAL TRANSPLANT PATIENTS IN GERMANY (THE PORTRAIT STUDY)

Author(s)

Neumayer HH1, Lopau K2, Glander P1, Detering J2, Chamberlain G3, Naik M1, Plesnila-Frank C4, Sabater FJ5, Bennett H3, Rosz D4, Sennfalt K61Charite Hospital, Berlin, Germany, 2University Hospital Würzburg, Würzburg, Germany, 3Swansea University, Cardiff, United Kingdom, 4Bristol-Myers Squibb Germany, Munich, Germany, 5Bristol-Myers Squibb, Rueil-Malmaison, Paris, France, 6Bristol-Myers Squibb, Rueil-Malmaison, France

OBJECTIVES: Little information is available on the prevalence of post-transplant events and resource utilization associated with such events in renal transplant (RT) patients in clinical practice in Germany. The PORTRAIT study aims to describe the health care resources used and to estimate the cost of managing post-transplant patients using observational data from transplant databases and physician questionnaires from transplant centers across Europe. Aggregated study results have been previously communicated; this abstract describes the results from two German centers. METHODS: A retrospective observational study was undertaken in which resource usage over three years was employed to derive costs  from a third party perspective, with results stratified by glomerular filtration rate (GFR) status at one-year post transplant. Descriptive statistics were used to detail medical resource use and its costs. Post-transplant events considered were: hospitals stays, delayed graft function, outpatient appointments, laboratory tests, anaemia, hypertension, dyslipidaemia and infections. Immunosuppressant drug costs were not considered in this analysis. RESULTS: Four hundred and fourteen patients from both sites were included in the analysis. The total three-year cost of post-transplant care by GFR at one year varies from a minimum of €20,632 per patient to a maximum of €43,163 per patient. The average three-year costs decrease as a result of improved graft functioning status (increased GFR) at one year. The average three-year costs for a patient with a GFR≥45mL/ min/1.73 m2 at one year are 40% lower than those patients with a GFR<30 mL/ min/1.73 m2.  CONCLUSIONS: In line with the multinational results, the German results provide evidence that post-transplant resource usage in a real-life treatment setting increases as post-transplant renal function worsens. Therefore management strategies that promote renal function post transplant are likely to provide important resource savings to the healthcare system.

Conference/Value in Health Info

2012-11, ISPOR Europe 2012, Berlin, Germany

Value in Health, Vol. 15, No. 7 (November 2012)

Code

PUK6

Topic

Economic Evaluation

Topic Subcategory

Cost/Cost of Illness/Resource Use Studies

Disease

Urinary/Kidney Disorders

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