OBJECTIVES: Health plans and other decision making bodies regularly request that pharmaceutical and biotechnology companies provide a standardized dossier containing detailed information - not only on the drug's safety and efficacy, but also on its overall clinical, economic, and humanistic value relative to alternative therapies.  Independent focus groups and multi-country surveys identified several challenges related to convenient, real-time collaboration to access information and tools developed by the pharmaceutical and biotechnology industry METHODS: In the US, the Academy of Managed Care Pharmacy (AMCP) partnered with Dymaxium Healthcare Innovations to launch an electronic platform to meet immediate needs of US (Health Care Decision Makers (HCDMs).  The platform would incorporate all the key components of decision making processes, and was designed with leading HCDMs.  A survey was also fielded to over 50 US decision makers and payers from 13 other countries to provide their feedback and input into their local HTA needs. Local country HTA guidelines and formats (i.e AMCP format in the US) from over 30 countries was incorporated into the overall design of the platform. RESULTS: The US HCDM survey results indicated the following challenges:  a) Difficulty navigating through large volumes of information (300+ pages) to use for internal reviews, b) Risks associated with review of information that is out-dated due to the release of newly published safety and effectiveness information, c) Lack of user-friendly, transparent models and tools that can be customized to reflect a plan’s own population patterns.  The international survey revealed similar challenges and unmet needs by HCDMs that were similar to their US counterparts.  This feedback is being incorporated into the development of international versions of the eDossier system. CONCLUSIONS:  Leading experts from regional countries validated the unique needs of each region in conducting HTA reviews and the various benefits an electronic platform such as the AMCP eDossier may provide.