OBJECTIVES: Peripheral neuropathic pain (PNP) is a complex type of pain initiated by a primary lesion or dysfunction in the nervous system and causes large impact on health related quality of life (HRQL). While PNP in diabetes is in focus much less attention is given to non-diabetic PNP. The main aims of present study were to screen patients in GP practices for non-diabetic PNP, assess their HRQL and explore key influential variables.  METHODS: Non-diabetic patients aged ≥30 years were recruited in 10 general practices in Hungary. At first, patients filled in the PainDetect Questionnaire (PD-Q). Patients achieving ≥13 PD-Q score (unclear or possible neuropathic pain) were further assessed by DN4 (Neuropathic Pain Diagnostic Questionnaire). The cut-off value for the diagnosis of neuropathic pain in the DN4 is a total score of 4/10. Patients with PD-Q score >18 or DN4 score ≥4 were considered to be PNP patients. They completed the EQ-5D questionnaire and GPs provided demographic data.  RESULTS: One hundred and eleven patients with non-diabetic PNP were selected. Among them there were more women (69%), mean age was 62 (SD=14) years. Only 15 (14%) patients have already had prior PNP diagnosis at inclusion. EQ-5D index showed 58% decrease compared to a perfect health state and 44% decrease to the gender and age matched Hungarian population (0.42 vs. 0.75, p<0.001). The pain/discomfort dimension was the most affected in the EQ-5D, 96% of patients reported some or serious problem. Similar ratios for mobility, self-care, usual activities and anxiety dimensions were 83%, 37%, 82% and 83%. Average (SD) EQ-5D score of patients with mild, moderate and severe average pain were 0.56 (0.29), 0.43 (0.29) and 0.29 (0.27). The differences were significant (p=0.014). CONCLUSIONS: Our research showed that non-diabetic neuropathic pain is poorly diagnosed and a strong relationship was demonstrated between neuropathic pain and HRQL.