OBJECTIVES: An update of health economics analysis of type 2 diabetes mellitus (T2DM) in adult population in Turkey was performed. The objectives of the analysis were to determine the direct cost components caused by T2DM and its complications and also the loss of work productivity in T2DM. In this presentation, data on work productivity are reported.  METHODS: Forty centres were selected from the list of centres in which adult T2DM patients were followed on a routine basis. These centres were representative of the country, since they were selected by two-stage cluster sampling. Data on work productivity were collected via “Work Productivity and Activity Impairment Questionnaire: General Health V2.0 (WPAI:GH)”.  RESULTS: A total of 657 patients’ data were included in the analysis. The percentage of patients, who had a job, at the time of the study conducted, was 14.0%. This figure was lower in patients with ophthalmic complications (8.7% vs. 15.9%; p=0.020) and with cardiovascular complications (4.1% vs. 15.7%; p=0.002). Mean scores of absenteeism, presenteeism and overall work productivity loss were 23.5±37.6%, 15.2±18.8%, and 38.6±37.8%, respectively. Overall impairment score of work productivity was 22.7±25.0%. Patients with metabolic complications and ophthalmic complications had reported more impairment (though non-significant) (for metabolic complications 32.4% vs. 19.4%; p=0.11; for ophthalmic complications 30.9% vs. 21.1%; p=0.10). Overall impairment score of daily activities was 31.3±29.2%. Patients with metabolic complications and cardiovascular complications had reported more impairment (for metabolic complications 43.1% vs. 26.3%; p<0.001; and for cardiovascular complications 37.7% vs. 30.2%; p=0.035).  CONCLUSIONS: DM is a disease that significantly impairs the opportunity to have a job, and also impairs the work productivity and daily activities of patients. This impairment is correlated with the presence of systemic complications. Thus, prevention or effective treatment of complications in DM is crucial to improve the social and economic consequences of the disease.