OBJECTIVES: To analyse the association between Health Related Quality of Life (HRQoL) and age, in hypertensive patients and the correlation between HRQoL reported by patients and evaluated by their doctors. METHODS: Observational, cross-sectional, multi-centre study, in Primary and Specialised Care. Inclusion of 5,031 hypertensive patients, selected by quotes according to three age groups (<65, 65-79, ≥ 80 years) was planned.  Selection criteria were:  patients whose age was over 18, diagnosed as having hypertension at least one year before inclusion and attended a follow-up visit. Information related to hypertension, basic socio-demographic and clinical data, the self-administered specific questionnaire MINICHAL for the evaluation of HRQoL (higher scores indicative of lower HRQoL), and a visual analogue scale (VAS) for the general evaluation of HRQoL (higher scores indicative of higher HRQoL) by patients and doctors, were recorded. Data of 4,346 eligible patients were included. HRQoL-age correlation was analysed by Spearman’s-rho, differences among age groups by Kruskal-Wallis and patient/doctor agreement by the intraclass correlation coefficient (ICC). RESULTS: Mean age (SD) was 68.35(12.60). 38.1% of patients were under 65, 36.9% between 65 and 80 and 25.0% were over 80 years old. 54.5% were men. Mean time since diagnosis was 10.33(7.68) years. 34.2% had a family history of high blood pressure. Mean scores in MINICHAL were: State of Mind dimension 8.07(5.83), Somatic Manifestations dimension 3.24(3.06). Worsening of both dimensions was found when comparing groups of higher age (p<0.001) as well as significant moderate correlations of both dimensions with age (0.335, p<0.001; 0.397 p<0.001). Mean(SD) VAS score for doctors’ evaluation was 66.84(15.82) and 63.93(18.46) that of patients; ICC for agreement was 0.697 (0.672, 0.687 and 0.663 by age groups). CONCLUSIONS: An impact of age on HRQoL worsening is evidenced. Patient/doctor agreement in the evaluation of HRQoL is adequate; however doctors trend to overestimate the HRQoL of patients.