OBJECTIVES: Implantable ports (IPs) are widely used in therapeutic areas where frequent vascular accesses are required. The use of IPs represents a practical solution and offers comfort to patients; however it is associated with significant obstruction rate, which may lead to high hospital costs. Single-hand secured Huber needles (SSHNs) are designed to reduce the frequency of catheter obstructions compared to two-hand Huber needles (THNs).To assess the economic and organizational impact of the systematic use of SSHN from a hospital perspective, a decision tree model was designed. METHODS: Resource consumptions and costs (Euros 2012) associated with the systematic use of SSHN and THN were collected in French hospitals of Paris area (AP-HP). Both strategies were evaluated along the reperfusion process (when it occurred). Probabilities of obstruction were extracted from published literature and estimated by experts when not available. Deterministic and probabilistic sensitivity analyses (DSA and PSA) were performed to appraise the uncertainty around estimated parameters; RESULTS: The simulation showed that the systematic use of SSHN is associated with lower hospital expenses compared to THN. Based on the use of 10,000 needles per year, its systematic use would save €27,360 annually (total cost of €147,540 versus €174,897). In particular, a total of €16,259 related to consumables and medical procedures would be directly saved from hospital budget. The remaining part would result in 0.13 nursing full-time equivalent (FTE) and 0.03 medical FTE, which could be reallocated to other activities. DSA showed that baseline obstruction rate is the most influential variable for annual cost and PSA confirmed that SSHN is the least expensive strategy. CONCLUSIONS: The reduction of use of consumables derived from the model was in line with observations in AP-HP. The systematic use of SSHN would probably lead to a reduction in expenses for hospitals, and staff time saved.