EQ-5D UTILITIES AND PRODUCTIVITY OF ADULTS WITH ATTENTION-DEFICIT/HYPERACTIVITY DISORDER- REVIEW OF THE LITERATURE AND A CROSS-SECTIONAL SURVEY IN HUNGARY
Author(s)
Péntek M1, Gulácsi L1, V. Hevér N1, Papp S2, Baji P3, Brodszky V1, Pulay AJ2, Balogh O1, Bitter I21Corvinus University of Budapest, Budapest, Hungary, 2Semmelweis University, Budapest, Hungary, 3Maastricht University, Maastricht, Netherlands
OBJECTIVES: To give a literature review and assess the health status utility and productivity of adult patients with attention-deficit/hyperactivity disorder (ADHD) focusing on measures with outstanding importance for health economic analysis. METHODS: PubMed was systematically reviewed for adult ADHD studies involving the EQ-5D and/or Work Productivity and Activity Impairment (WPAI) questionnaires. A cross sectional survey in an outpatient psychiatry centre was performed and the Clinical Global Impression scale (CGI-S) was used to categorize patients by severity. RESULTS: While several studies assessed the impact of ADHD in childhood only one (Patient 2011;4(4):247-57) dealt with EQ-5D in adult patients and none applied WPAI. In our survey, forty-four patients (males 79.5%) were involved with mean (SD) age of 30.0 (9.9) years and disease duration of 7.6 (6.6) years. Thirty-three (75%) were singles, 9 (20.5%) married (20.5%), 2 (4.5%) divorced and 9 (20.5%) had children. Highest educational level was primary, secondary school and university at 5 (11.4%), 22 (50.0%) and 17 (38.7%) cases, respectively. Twenty-nine (65.9%) were taking medication for ADHD, seven (15.9%) needed accompanying person when travelling for health care. Injury requiring medical care occurred at 6 (13.6%) patients, 4 related to ADHD by self-report. Usual activities, pain/discomfort and anxiety/depression were the most affected EQ-5D dimensions (moderate problem: 52.3%, 47.7%, 54.5%) and the EQ-5D score (mean 0.747, SD 0.280) was significantly lower than the age-matched population norm (p<0.05). Utility in mild (CGI-S=3) and moderate (CGI-S=4) health state was 0.799 and 0.706, respectively. Twenty-three (52.3%) patients were working, 17 (38.6%) were students and 4 (9.1%) unemployed. WPAI results were as follows, mean (SD): absenteeism 0.1 (0.3)%, presenteeism 33.0 (26.2)%, overall work impairment 16.9 (22.8)%, activity impairment 39.5 (28.7)%. CONCLUSIONS: Health status utility and productivity in adult ADHD is underexplored. Our study suggests that impaired everyday activities and preseenteism are considerable and deserve further research.
Conference/Value in Health Info
2012-11, ISPOR Europe 2012, Berlin, Germany
Value in Health, Vol. 15, No. 7 (November 2012)
Code
PMH35
Topic
Patient-Centered Research
Topic Subcategory
Health State Utilities
Disease
Mental Health