OBJECTIVES: In Italy the epidemiological data and the Dupuytren disease care practice description  are poor and come mainly from extrapolation of data obtained in other countries. The objective of this study was to assess the prevalence and the management of this disease in Italy and in the Italian regions. METHODS: Data have been obtained from CSD LPD General Practitioner’s (GPs) longitudinal database. Patients with at least one diagnosis of Dupuytren disease between October 2008 and September 2010 were selected. Patients were followed-up for 12 months since the First Diagnosis date. Study results have been stratified by macro areas. RESULTS: 1.829  patients (62,55% men, 37,45% women) with at least one diagnosis of Dupuytren disease have been selected. Disease prevalence was estimated at 0,15% patients nationwide and at 0.178% , 0.229%, 0.123% ,0.082% patients in the Nord-West, Nord-East, Center and South-Islands respectively. Prevalence increased with age: 35% of the patients were aged over 65 y. Only 32 % of the patients benefited from a specialist visit request for the Dupuytren disease during the follow-up period; 70,7% of those requests were for orthopedic visits, 13,5% for hand surgery and 7,5% for physiatry. Macro area analysis showed some differences in the specialists visits distribution. CONCLUSIONS: The prevalence analysis showed a slight difference among macro areas underlining a major prevalence of the disease in the Nord-East compared to the South–Islands area. The prevalence of the disease in the CSD LPD database in Italy was of 0.15% which is significantly lower than that reported in the literature. This is probably due to the fact that the majority of Dupuytren published studies were conducted in Nordic countries where the disease is mainly diffused. Also, the data collection methods and the age groups could be different, and, further, many researches were carried out in a specialist setting only.