OBJECTIVES: Reaching target dose of neurohormonal blockade drugs is crucial for health outcomes in chronic heart failure (CHF). Our aim was to present dosage analysis for CHF therapies. Our calculation was presented on the basis of representative patient attendance data from the National Health Insurance Fund Administration (NHIFA) in Hungary. METHODS: NHIFA database uniquely contains detailed provision data (medicine, out- and inpatient services) from the whole Hungarian population of 10 million. All financed health care providers use the same report structure and reported data are strictly validated. Our retrospective analyses included data of 2004-2010 for all patients with chronic heart failure (ICD code I50) as main diagnosis. Rate of therapy and dosage pattern were analysed on the basis of prescription data. Real world dose of therapy was estimated as filled volume per time between prescription fill. Estimated dose per day was aggregated on half year basis from the first medicine record. On the basis of histological data titration patterns were analysed as well. RESULTS: Merely 80% of CHF patients is treated with adequate therapy. Results for dosage patterns showed, that patients are not reaching target dose in practice, and titration process is suboptimal as well. CONCLUSIONS: Patient and disease management program of CHF patients could improve health outcomes by enhance treatment effectiveness.