OBJECTIVES: The excessive and often unnecessary prescription of antibiotics and the resulting increase in antibiotic resistance poses a serious medical problem. The analysis provides data for assessing a health insurance company's strategies aiming to optimize antibiotic prescribing due to a quick C-reactive protein testing.   METHODS: Within a period of 22 months (January 2009 – October 2010), in a population sample of 365 690 insured persons from Slovakia, a connection was studied between availability of a quick C-reactive protein testing as a service furnished by medical care providers and a final cost of antibiotic treatment. A health insurance fund provided data for this analysis. RESULTS: Higher consumption of antibiotics can be linked to higher resistance to antibiotics. On the other hand this linkage is not linear. In the analysis, the average expenditure per 1 patient at the level of 1.12 € can be seen within GPs, where a quick C-reactive protein testing is available. On the other hand, the average expenditure per 1 patient at the level of 1.35 € can be seen within GPs, where a quick C-reactive protein testing is not available.  The average expenditure per 1 pediatric patient at the level of 1.64 € can be seen within pediatric medicine, where a quick C-reactive protein testing is available. However, the average expenditure per 1 pediatric patient at the level of 2.33 € can be seen within pediatric medicine, where a quick C-reactive protein testing is not available. Based on the analysis, we can finalised that in the case of an appropriate use of C-reactive protein testing with the monitored sample of 365 690 insured persons within the above mentioned period of 22 months, financial resources in a total amount of 340 000 € could have been saved.   CONCLUSIONS: Adherence to principles of good antibiotic policies leads to fundamental short and long term financial savings within the budget of a health insurance fund.