OBJECTIVES:  The Brazilian National Immunization Program currently offers 10-valent Pneumococcal Conjugated Vaccine (PCV10) to all children less than 5 years of age for free. The current study was developed to compare the costs of PCV13 vaccination plus campaign for corporations, versus a hypothetical scenario where the corporation would incur in the expenditures to do the campaign as proposed for PCV13 while vaccinating with free PCV10 under the corporative payer perspective. METHODS: A cost minimization analysis was developed considering vaccination costs, campaign and health management costs, wage and productivity loss from employee absence due to child disease and the vaccinations. Clinical events were retrieved from Pepe et al 2009, absence days due to health events were retrieved from the average hospitalization days from DATASUS 2012 and ambulatory use was limited to 1 absence day. Total employee absence days were halved assuming a partner outside the company to take care of the sick child and to take it to the vaccinations. Average wage was retrieved from the Brazilian Institute for Geography and Statistics 2011 data (IBGE) and production was estimated from the indicator ‘revenue generated by the employee’, from a market research developed by Exame magazine in 2011 using IBGE and the Brazilian Central Bank data. The base case considered a real scenario from a large corporation in Brazil. Values were expressed in 2011USD. RESULTS: Independent campaign with zero cost PCV10 and PCV13 vaccination plus campaign totaled 67,90USD and 114,65USD per employee respectively. Productivity loss was estimated to be 879,07USD and 667,89USD per employee for PCV10 and PCV13 respectively. Considering all evaluated costs, PCV10 and PCV13 totaled 946,97USD and 782,54USD per employee respectively. CONCLUSIONS: The PCV13 vaccination plus campaign initiative is estimated to save costs (164,42USD/employee), when compared to developing an independent campaign, mainly driven by productivity loss at the corporative payer perspective.