OBJECTIVES: For over 40 years, “dermo-cosmetics”, or “cosmeceuticals”, have been identified with the field of cosmetics and hygiene products adhering to the rules of good practice of pharmaceutical science. Paradoxically, while “dermo-cosmetics”, or “cosmeceuticals”, are developing and now concern all age groups of the population, there is no quality-of-life questionnaire available to assess the impact of this treatment on quality of life.The evaluation of its impact in terms of quality of life is however a bold, ambitious and also necessary step. The CosmeceutiQoL has arrived to fill this gap. . The objective of this evaluation was to test the CosmeceutiQoL’s sensitivity to change in women using a dermo-cosmetic. METHODS: Women aged 22 to 66y and users of Tolerance Extreme DEFI were recruited in French pharmacies. They completed the CosmeceutiQoL on inclusion and on the 7th and 14thday. An irritability and Sensiscale score were also taken. RESULTS: Fourty-four women aged 22 to 66y, 72% report using day cream, 42% a night cream. The irritability score, measured using a visual analog scale, was 4.2 at baseline. Sensitivity, measured using the Sensiscale, was 43.3 at baseline. The CosmeceutiQoL score was 42.5.On the 7th and 14thday, the irritability score was 2.39 and 1.23 and the Sensiscale was 19.80 and 7.03 respectively. During the same time interval, the CosmeceutiQoL scores were 53 and 71. For the three scores, there was a statistically significant improvement in the score from the 7th day. This improvement was confirmed on the 14th day. There were no significant differences according to the patient’s age. CONCLUSIONS: The CosmeceutiQoL questionnaire was created and validated in 2010. Its objective was to assess a dermo-cosmetic’s impact on the quality-of-life of women. The significant improvement in the score from the 7th day, maintained on the 14thday, confirms the relevance of this questionnaire.The CosmeceutiQoL’s reproducibility was confirmed during questionnaire validation, and this evaluation validates sensitivity to change.