OBJECTIVES: To compare work productivity impairment between Russian patients with those in the 5EU and US and assess whether conditions have similar impact across these geographies.   METHODS: The study included data from the 2011 Russia (N=10,039), US (N=75,000), and 5EU (N= 57,512) National Health and Wellness Survey, a survey representative of urban adults in Russia and total adult populations of the US and each 5EU country.  Respondents self-reported physician diagnosis of type 2 diabetes (T2D) and cardiovascular (CV) conditions, as well as their height and weight used to calculate obesity (BMI≥30).  Work productivity impairment and impairment in non-work activities was assessed with the Work Productivity and Activity Impairment (WPAI) questionnaire.  Two-way ANOVAs tested for differences in work productivity impairment by geography and condition. RESULTS: There were regional differences in mean health-related work impairment, with Russia the highest (22.6%), followed by 5EU (19.4%) and US (14.9%; p<0.001).  Collapsing across geographies, obesity, T2D, and CV conditions were each associated with more impaired work productivity (all ps<0.01), but the magnitude of the decrement associated with each disease depended on region (all ps<0.01).  The incremental work productivity loss associated with obesity was smallest in Russia (1.5%), compared with 5EU (3.9%) and US (2.7%).  T2D patients in Russia and 5EU experienced similar incremental work productivity impairment (8.5%), while US T2D patients showed a difference of 5.0%.  Similarly, Russians with CV conditions were more impaired than in 5EU and US when compared with non-CV patients (8.1% vs. 7.1% and 4.4%, respectively). CONCLUSIONS: Russians have greater health-related work impairment than adults in US and 5EU. The incremental burden of obesity, T2D, and CV conditions in Russia appears to differ from the US and 5EU, being relatively small for obesity but greater for T2D and CV conditions. These differences highlight the importance of country-specific information for these markets.