OBJECTIVES: To carry out a clinical-economic analysis of MoliCare® Premium extra soft diapers application efficiency for contact dermatitis* and pressure ulcers prophylaxis with immobile urinary-incontinent patients.  METHODS: Estimation of typical management practice with immobile urinary-incontinent patients’ having developed contact dermatitis* or pressure ulcers was performed by means of experts’ questioning. Only direct medical costs were taken into account in the research. A comparative clinical-economic analysis was performed using Markov’s model. A sensitivity analysis was performed taking into account retail and wholesale prices for absorbing means and skin care agents.  RESULTS: Twenty weeks’ total costs calculated with Markov’s model use for contact dermatitis* and 1-4 degree pressure ulcers prophylaxis and treatment with one immobile urinary-incontinent patient with absorbent means and skin care agents’ application were 5508 € in retail prices and 5276 € in wholesale prices; without their application the costs were 7 446 €. Overall this Analysis shows that medical-prophylactic institutions’ costs for contact dermatitis* and pressure ulcers’ prophylaxis and treatment with one immobile urinary-incontinent patient without absorbing means and skin care agents applying are considerably higher (by 41%) than when they are applied. At the same time indirect costs including linen disinfection, washing, drying and ironing were not taken into account and such costs can increase a costs’ total figure.  CONCLUSIONS: Absorbent means and skin care agents’ application for contact dermatitis and pressure ulcers prophylaxis and treatment with immobile urinary-incontinent patients is a dominant technique and cost efficacy of using absorbent means and skin care agents was demonstrated. The Branch standard “Patients’ management protocol. Pressure ulcers” (2002) needs actualization taking into account the data obtained in the present clinical-economic research.