OBJECTIVES: The UK Government has allocated £200 million per year for three years to fund cancer drugs in England which will be managed via the Cancer Drugs Fund (CDF). There are ten CDFs in England which are largely managed by Cancer Network Pharmacists. The objective of this research was to identify from the Cancer Network Pharmacists’ perspective what impact the CDF had made in the first year on cancer drug usage, practice, use of resources and also their concerns if the CDF disappeared after three years. METHODS: A semi structured questionnaire was developed to capture quantitative and qualitative data relating to changes in oncology drug use, clinical practice and resources for the time period 1st April 2011 to 31st March 2012.This questionnaire was also used to capture information on the Cancer Network Pharmacists concerns if the CDF disappeared after three years. The questionnaire was piloted with three Cancer Network Pharmacists. Telephone interviews were undertaken with  Cancer Network Pharmacists covering the ten CDFs. The data collected was assessed and evaluated, using a thematic framework. RESULTS: The CDF had led to a significant increase in use of some drugs and clinical practice had changed. Workload for pharmacy both at the cancer networks and in the hospital Trusts had increased. Attendances at clinics had increased creating some capacity issues. The commissioning process for cancer drugs had changed; new drugs were not commissioned unless recommended by NICE. It was considered there would be significant risks if the CDF disappeared after three years as it was not clear how drugs funded by the CDF would then be funded and return to practice pre CDF would be difficult. CONCLUSIONS: The CDF had changed clinical practice for the management of certain cancers. If the CDF disappeared in 2014 it was unclear how some drugs would be funded.