OBJECTIVES: To develop an off-the-shelf catalogue of quality improvement (QI) interventions to implement for preventing hospital-acquire pressure ulcers (HAPUs).  In 2007, the Institute of Healthcare Improvement (IHI) released a 17-item best-practice framework of general QI interventions organized into four domains of hospital practice: Leadership; Staff; Information & Information Technology; and Performance & Improvement.  Since HAPU prevention has become a burgeoning international topic because of its monetary burden on health care, clinicians have investigated novel methods to bolster HAPU prevention guidelines.  QI interventions pose a promising resource for improved HAPU outcomes. METHODS: Starting with the IHI best-practice framework, fourteen leading experts in QI and HAPU prevention at academic tertiary care facilities were interviewed in-person to qualitatively augment the list of QI interventions to reflect HAPU-specific preventive QI interventions.  The respondents possessed backgrounds as physicians (6), wound care nurses (4), QI experts (2), and outcomes researchers (2).  Interviews followed a structured outline of the best-practice framework, in which they were allowed to add, delete or modify QI interventions within each domain as they pertained to HAPU prevention. RESULTS:  The series of qualitative interviews resulted in successful augmentation to IHI’s best-practice framework of QI interventions to more accurately reflect current practice in HAPU prevention.  The HAPU-practice framework contains seven Leadership items, six Staff items, four Information & Information Technology items, and eight Performance & Improvement items.  Of these items, four were removed from the original framework, twelve were added, and all remaining items were modified in some manner. CONCLUSIONS: This qualitative study provides an off-the-shelf catalogue of QI interventions that wound care teams can utilize for preventing HAPUs and possibly other hospital-acquired conditions.  For further consideration, the field would benefit from comparative effectiveness research about QI interventions and strategies for HAPU prevention that hospitals can then focus their efforts toward.