OBJECTIVES To explore how driving status and bilateral visual acuity (best-eye (BEVA) and worst-eye (WEVA)) impact quality of life (QOL) in patients with NV-ARMD in terms of health utility (HU) derived from the EuroQol (EQ-5D) and QOL derived from the National Eye Institute Vision Function Questionnaire (NEI-VFQ 25). METHODS This cross-sectional data (n = 154) at screening from a phase I/II clinical trial in patients with NV-ARMD was conducted in 4 countries. Patients were stratified into 4 severity groups (BEVA, 20/40; WEVA, 20/200). Four driving statuses were extracted from NEI-VFQ 25 questions 15a and 15b, including current drivers (D), never drove (ND), non-drivers who gave up driving because of eyesight (GDE), and non-drivers who gave up driving because of other reasons (GDO). We performed analysis of variance to estimate differences among different driving statuses for the HU and all QOL scores. Least squares means adjusted on bilateral VA, age, gender, and country were calculated. RESULTS ND group reported significantly lower HU than D group (p=0.0006). Seven out of 10 vision functioning scores, general health score, and composite score of ND group were also lower than D group (p<0.05). GDE showed lower mean scores for all the QOL dimensions when compared to D group while GDO had no difference. Patients with better WEVA (BEVA<20/40:WEVA≥20/200) reported higher scores on the NEI-VFQ 25 dimensions of dependency, near vision, and driving as well as the composite scores than patients with worse WEVA (BEVA<20/40:WEVA<20/200) (p<0.05). CONCLUSIONS The results of bilateral visual acuity show different impacts on vision functioning. When BEVA falls below 20/40, WEVA severity resulted in higher burdens on overall vision related QOL as well as dependency and near vision functioning. Driving status is shown to be significantly associated with QOL. Physicians should be aware of driving status when evaluating QOL in patients with NV-ARMD.