OBJECTIVES To summarize the efficacy/effectiveness, complications and patient reported outcomes associated with the polypropylene mesh kit GYNECARE Prolift® Pelvic Floor Repair System. METHODS A systematic literature review was conducted using MEDLINE, PUBMED and gynecologic conference abstracts from AUGS, IUGA and SGS for primary research focusing on the use of GYNECARE Prolift® from 2005-2008. Included studies needed to report on outcomes after any GYNECARE Prolift® regarding efficacy/effectiveness or safety of Anterior, Posterior or Total Repair. Single case studies, review articles, meta-analyses, non-English language studies and small case series (n<10) were excluded. Kin study results were included only from the primary article. Weighted averages and confidence intervals were calculated. RESULTS Among 33 independent studies included, mean (SD) follow-up time was 7.2 (4.6) months (95% CI: 7.0-7.4) among 24 studies reporting mean; and median follow-up reported was 7-19 months (data range: 2-30) for 9 studies. Objective anatomic success rates were 89.5% (95% CI: 88.2-90.6; n=2614) for all GYNECARE Prolift®, and 89.5% (86.5-92.0; n=532) for anterior, 92.0% (88.8-94.5; n=386) for posterior and 91.3% (87.6-94.2; n=311) for total repairs, respectively. Overall recurrence rate (any compartment) was 9.3% (8.2-10.6; n=2217). Complication rates were: overall rate of any injury (Bladder, Bowel, Vaginal or Urethral) 1.7% (1.4-2.2; n=4,750) of which bladder injury/perforation was the highest relative to other rates: 2.3% (1.8-3.0; n=2486). Exposure rates were 6.9% (6.0-7.8; n=2985). Mesh excision/ resection was reported at 6.4% (5.1-8.1; n=1087). Dyspareunia rates were 6.7% (5.3-8.3; n=1092). Patient satisfaction was 82.3% (77.0-86.9; n=244) and 87.5% reported they would “recommend to a friend” (81.0-92.4; n=144). CONCLUSIONS The evidence for mesh-based repairs is growing. While more randomized, and appropriately powered trials are needed to understand longer-term outcomes, current peer-reviewed data shows that the GYNECARE Prolift® kit is an effective pelvic floor repair device with limited complications and high patient satisfaction.