OBJECTIVES 1) To assess tobacco quit rates among a convenient sample of current smokers who participated in the community pharmacist-based program, and 2) to identify the predictors of quitting over a 6-month period among the study population. METHODS Each year approximately 200 patients were enrolled across 15 pharmacies throughout New Mexico. Pharmacists, who had received the Rx for Change training, provided the cessation program with administrative and clerical support from the Pharmacy Technicians. Patients were provided counseling services at no charge and, if necessary, received medications without charge. Patients did not receive any monetary compensation for participation. Data on patient's demographic information, smoking status, and readiness for quitting was collected at the initial enrollment. Data on smoking status was collected at 1, 3, and 6 months. Statistical Analysis: Missing data on follow-up was imputed using the last observation carry forward method. Smoking cessation rates were calculated at 1, 3, and 6 months. Multiple Logistic regression analysis was performed to assess predictors of quitting. Standard errors were adjusted for repeated observation. RESULTS Final sample size was 346 participants. The average quit rate at the end of 6 months was 25%. Significant predictors of quitting were high confidence levels in quitting at baseline (OR= 2.628; p=0.000), individuals who had their first cigarettes at least 30 minutes after waking up), first cessation attempt, and non-white patients were more likely to quit. CONCLUSIONS Smoking cessation program delivered through trained community pharmacists is an effective approach in reducing smoking. Future research should be conducted to compare the effectiveness of pharmacists with other providers of tobacco cessation services.