BACKGROUND: As electronic patient-reported outcome (ePRO) use expands, questions have arisen regarding the effect of presentation form and style on patient interpretation and whether there is an optimal format to ensure clarity, ease of use, and data quality. OBJECTIVES: To develop and validate a standardized ePRO interface of common PRO question formats for use on desktop and tablet PCs to streamline ePRO study implementation. METHODS: A web-based application was developed for desktop and tablet platforms with 52 demographic and clinical questions representing Likert-type, dichotomous, VAS and numeric rating scales. Adults from the general population were recruited through newspaper advertisements to participate in questionnaire completion and a cognitive debriefing interview. Participants answered questions on either desktop or tablet PC and then reviewed the alternate format during the interview. Alternative question formats were reviewed to obtain further respondent insight and recommendations. RESULTS: Participants: N=47: mean age 54 years (23 to 79), 51% female; 49% reported a chronic condition. 13%