OBJECTIVES Premenstrual Syndrome (PMS) and Premenstrual Dysphroric Disorder (PMDD) can have significant impact on women's work productivity. This study objective was to assess the degree of productivity impairment associated with PMS and PMDD. METHODS Data were collected through an online survey of adult employed females aged 18-45 years (N=634), with some premenstrual complaints such as irritability, depression, headache, and abdominal bloating. Responses from the Work Productivity and Activity Impairment Questionnaire (WPAI) and the Work Limitations Questionnaire (WLQ) and its subscales (Time Management, Physical, Mental/Interpersonal and Output) were analyzed. The retrospective criteria of the American College of Obstetricians and Gynecologists and the DSM-IV-TR were used to identify women with Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) respectively. The study controlled for age using multivariate ANOVA and compared the following groups: 1) women that did not meet criteria for PMS or PMDD (66.4%); 2) women that met the criteria for PMS but not PMDD (18.9%); and 3) women that met the criteria for PMDD (14.7%). RESULTS Multivariate ANOVA showed significant differences across the three groups for the composite Productivity Loss of the WLQ and its subscales as well as for the WPAI (all p<0.001). When compared to women without PMDD or PMS, the model estimated greater work impairment scores for the PMDD group than for the PMS group. Post-hoc analysis revealed significant differences in scores between all groups for all outcomes (p<0.05) except between PMS and PMDD groups for the WLQ-Time Management and PMS and non-PMS/PMDD groups for the WLQ-Physical. CONCLUSIONS Presence of PMS and PMDD substantially impairs women's work productivity.