OBJECTIVES: Skeletal related events (SREs) are a major cause of morbidity for castration resistant prostate cancer (CRPC) patients with bone metastases. SREs can have a debilitating effect on patient’s quality of life (QoL), although severity depends on the type of SRE. The purpose of this study is to determine what data are available on utility weights by SRE type for use in a cost-utility analysis of CRPC. METHODS: A systematic literature review of PubMed was performed to identify data on SRE utilities. The search was limited to the past 10 years and to metastatic cancer and bone neoplasms. RESULTS: The search yielded 82 articles, of these 19 contained SRE and utility information only 8 of which reported utility weights. One article reported a utility decrement for hip fractures (0.03) in CRPC. Another reported utility decrements for pathologic fractures (0.13) and radiation to bone (0.07) in metastatic prostate cancer (mPCa). Two articles contained utility data differentiated per SRE for non-small-cell lung carcinoma (NSCLC) and advanced renal cell carcinoma (aRCC). These decrements were calculated using a multiplier per SRE derived from an earlier study in metastatic breast cancer (mBCa) and ranged from 0.05 for vertebral fractures to 0.50-0.61 for spinal cord compression. The other 4 articles only reported the overall utility, but did not specify per type of SRE. CONCLUSIONS: To accurately model the impact of SREs on CRPC, QoL utility weights should be assigned to each SRE type to account for their varying severity. This study found only one article with a utility weight for a specific SRE in CRPC and one for mPCa. However, the use of SRE utility weights derived from a mBCa study for measuring SRE decrements in NSCLC and aRCC suggest SRE utility weights derived from other cancers may be acceptable for a CRPC cost-utility analysis.