OBJECTIVES: To assess the health status and health related quality of life among rural population residing in coastal region of South India. METHODS: Randomly selected population attending health awareness camp in rural village of South India were recruited for the study. Kannada version of EQ-5D5L questionnaire was used to assess the health related quality of life. Both descriptive and VAS scores were used for assessment. The population recruited was having the age >18 years and <75 years having the family history of either diabetes, CVD or both. RESULTS: A total of 126 patients were recruited with the mean±SD age of 45.95±13.44. The descriptive scores ranging between minimum 1 and maximum 5 for different health related quality of life indicators were, mobility score 2.11±0.88 (mean±SD), self-care score 1.55±0.83, activity score 2.07±0.94, pain score 2.38±0.86 and anxiety score of 1.96±1.01. Among the different health states, 11,121 health state was found as more common (mode). The VAS score found to be 67.56±14.64. CONCLUSIONS: There was considerable impact of pain and activity on the health related quality of life among rural coastal population in south India who had the family history of diabetes, CVD or both. There is a need to study the risk factors and other quality of life indicators among the rural costal population in India.