OBJECTIVES: This study aimed to develop cost-effectiveness analysis of Soft Silicone Wound-Contact Dressing (SS) versus Silver Sulphadiazine (SSD) in children with partial-thickness scalds (PTS), under the perspective of Brazilian public payers. METHODS: A literature search was conducted to gather efficacy data for SS and SSD and identified one randomized controlled trial that compared median time to 100% epithelialization (MTH) for SS and SSD. These data were used to estimate clinical benefits in terms of “inpatient days avoided”. The model assumed that SSD is the current practice in Brazilian public hospitals and patients are discharged at the time their wound heals. Resource use was estimated through expert panel, only direct medical costs were included in the analysis and unit costs were obtained from Brazilian official price lists.  RESULTS: The randomized trial observed MTH of 10.5 and 27.6 days for SS and SSD, respectively (incremental effectiveness of -17.1 days). Evidence from smaller observational studies have reported intervals to SS change of up to 14 days, while SSD requires two changes per day. Thus, the model estimated costs for the inpatient period assuming one dressing change for SS and 28 changes for SSD. The cost per dressing change was estimated as 33BRL for SS and 23BRL for SSD and the overall treatment costs were 1,261BRL and 23BRL. SS-related incremental costs were -1228BRL indicating a cost-saving profile. Benefits in terms of reduction in length of stay were not accounted in the base case scenario. If average public hospital daily charges were included in the cost estimation, savings would reach -2209BRL. CONCLUSIONS: SS dressing has shown higher efficacy when compared to SSD, with fewer overall costs. The significant reduction in the median time to healing offset the higher unit cost by lowering the number of required changes and the total length of stay.