OBJECTIVES: Chronic obstructive pulmonary disease (COPD) has a great impact on patient’s health-related quality of life (HRQoL). The aims of this study were: 1) to assess the generic and disease specific HRQoL of COPD patients, and 2) to evaluate the influence of age and lung function on the patient’s HRQoL. METHODS: In this observational, cross-sectional study the following information was obtained: age, lung function (post-bronchodilator forced expiratory volume in one second [FEV1]) and HRQoL (generic: EuroQol five-dimension questionnaire [EQ-5D], disease specific: St. George’s Respiratory Questionnaire [SGRQ]). Multiple linear regression model was applied to analyze the effect of age and FEV1 on the HRQoL. RESULTS: Data collected from 170 patients (mean age 63.8 years, 41.8% male) were analyzed. The mean EQ-5D score was 0,55 (SD=0,21) and the mean SGRQ total score was 56,22% (SD=16,19). The multiple linear regression model was successfully applied to describe the effect of age and FEV1 on the patient’s HRQoL measured by either EQ-5D (R2=0,47) or SGRQ (R2=0,64). Both generic and disease-specific HRQoL were related with age and lung function (p<0.005). CONCLUSIONS: SGRQ and EQ-5D appear to be reliable and valid for the assessment of HRQoL in COPD patients and may be used as a non-invasive patient-centered monitoring system as a guide for the management of COPD. Due to the simplicity of EQ-5D, the use of this instrument can be recommended within routine clinical practice.