OBJECTIVES: To better understand antidepressant-related weight gain and its association with medication adherence in employees experiencing depression. METHODS: Employed individuals (≥18 years of age) with diagnosed depression (excluding bipolar disorder) completed a web-based computer-generated 25-minute survey (population identified by Harris InteractiveTM).  Antidepressant adherence was quantified via 8-item Morisky Medication Adherence Scale (MMAS-8) where scores of 0, 1-2, and 3-8 were categorized as high, medium, and low adherence, respectively.  Weight gain was measured using the Toronto Side Effects Scale which measures medication-related side effects in the 2-weeks preceding the survey, and analyzed as a 4-level ordinal variable (none,