OBJECTIVES: To understand the association of antidepressant-related sexual dysfunction with degree of enjoyment and satisfaction from daily activities, and current medication. METHODS: Employed individuals (≥18 years of age) with depression (excluding bipolar disorder) completed a web-based computer-generated 25-minute survey (population identified by Harris Interactive).  Sexual dysfunction (SD) was assessed using the Arizona Sexual Experience (ASEX) Scale on 5 components of sexual functioning (Drive, Arousal, Penile Erection/Vaginal Lubrication, Orgasm, Satisfaction); each rated on a 6-level ordinal scale (higher scores indicate increased SD).  Using distribution among current antidepressant users, overall SD score was categorized into quartiles (lowest quartile represented better sexual functioning). Degree of enjoyment and satisfaction related to general activity and current medication was measured using a 5-point ordinal scale (1=very poor and 5=very good) using the Quality of Life Enjoyment and Satisfaction Questionnaire – Short Form (QLESQ-SF).  A summary “percent-of-max” score for general activity items, transformed to 5-level ordinal variable employing cut-points of 20, 40, 60 and 80%, was used (<20% represented the poorest experience). Gender stratified cumulative logit models were used to estimate effect of SD on QLESQ measures. RESULTS: Of 1,521 respondents, 872 (57%) reported current antidepressant use (60.6% female, mean age 49.9 ± 13.5 years).  Among antidepressant users, compared to the first SD quartile, odds of being in a poorer overall “percent-of-max” score (i.e., lower enjoyment/satisfaction) were greater in the highest (4th) SD quartile for both males (odds ratio [OR] =3.03; p=0.0007) and females (OR=1.96; p=0.0021).   Sexual dysfunction was associated with lack of satisfaction with medication for both genders: (males - 3rd SD quartile (OR=2.17; p=0.001); highest SD quartile (OR=3.33; p=0.0003); females - highest SD quartile (OR=1.49; p=0.06)). CONCLUSIONS: These data suggest that antidepressant-related SD may be associated with diminished enjoyment and satisfaction with daily activities and current medication. Such perceptions may impact eventual treatment outcomes.