Objective: To describe the trends of intra-hospital mortality, length of stay (LOS) and readmissions of patients with acute stroke at the National Healthcare Group (NHG), Singapore, 2000-2006. Methods: All patients aged 21+ years discharged with a primary diagnosis of stroke (ICD9CM 430-435) from the three public hospitals in NHG from January 2000 to December 2006 were studied. Data extracted from computerized datamart included demographic characteristics; co-morbid conditions; and outcomes of interest; i.e. LOS, intra-hospital mortality, and readmissions within one, three, and six months of discharge. Patients were stratified into hemorrhagic stroke (HS), ischemic stroke (IS) and transient ischaemic attack (TIA). Data were analysed by one-way ANOVA, logistic regression and chi-square test using SPSSv15. Results: During the period 2000-2006, there was a total of 22,428 deaths and discharges of patients with acute stroke. Prevalence of hypertension was highest in HS (>60%), with the rate decreasing significantly from 2000-2006 (p=0.001). However, the prevalence of dyslipidaemia was highest among in IS, with a significant increase in rate in all during the period in all types of stroke (p<0.001). Overall, HS was associated with highest intra-hospital mortality rate (95%CI: 22.3%-24.3%) and longest average LOS (95%CI: 17.1-18.7 days). A significant increasing trend in average LOS (p<0.001) was noted in both HS and IS. Readmissions within the 1-month, 3-month, and 6-month all decreased significantly over the period (p<0.001). The readmission rates within 1-month for HS and IS were higher than that of TIA, while there were no difference in readmission rates within three (5%) and six (6%) months for all stroke types. Conclusion: More studies into the causes of increased LOS should be carried out. Targeted primary interventions are needed to address the high rates of hypertension among those with IS and the increasing trend in dyslipidaemia among all types of stroke.