Objective: Hodgkin's lymphoma (HL) significantly impacts the health related Quality of Life (HRQoL) of patients. Treated patients often report increased stress, fatigue, nausea, sexual dysfunction, decreased social and emotional function, and vocational limitations; however few studies have assessed these domains. This review summarizes the impact of HL on hrQoL and recommends which HRQoL constructs should be assessed in the clinic and in clinical trials. Methods: A systematic review of the literature was conducted in order to better understand the impact of HL and its treatments on HRQoL. The identified articles were reviewed for references to HRQoL and specific tools to assess these constructs. The major impacts of the disease and treatment effects are compared across tools assessing these domains. Results: Some 30 published studies assessing hrQoL in patients with HL were identified. In these 30 articles over 20 instruments were used to assess HRQoL. The most common cancer-specific instruments employed were the EORTC QLQ-30 and various fatigue scales. No HL specific instrument was identified as being widely used. Tables summarizing the domains covered by each instrument are provided. The EORTC and FACT-Lym appear to provide the best coverage of relevant HRQoL domains, however, using more than one instrument is necessary to capture all relevant domains. Conclusion: Although HL significantly impacts HRQoL very few studies have collected this data in a comprehensive manner. This work reviews the literature on the HRQoL in patients with HL and provides insights regarding the key set of HRQoL constructs that should be assessed in the clinic and in clinical trials to best characterize the impact of HL and treatment. Although the FACT-Lym provides good coverage of HRQoL domains in HL, additional validation work is needed to ensure the reliability and validity of the tool in this population.