Objective: To evaluate the effectiveness of a patient- and physician-directed communication program to consider initiation of statin therapy among diabetics. Methods: Educational letters were sent to physicians and patients from a large commercial health plan. Physician- and patient-directed letters were sent to 593 and 579 patients respectively. Letters to the physicians were sent prior to the patient letters. Diabetic patients absent of statin treatment in a prior 120-day period were identified. Continuous eligibility was required for the evaluation and only patients over 17 years of age were included. Patients were observed for adding a statin during a 120-day follow-up period. Controls were identified from four other plans with similar characteristics. One-to-one case-control matching and t-test were performed to evaluate the effect of the interventions. Regression analyses were performed to determine the predictors of intervention responsiveness. Results: Mean age for patients in the program was approximately 55 years. There were 760 unique patients in both the patient and physician intervention components. Overall, 170 (22.4%) and 112 (11.0%) patients added a statin in the case versus control group (difference 11.4%, p<0.0001). Specifically, among the physician intervention component there were 17.8% and 11.6% of cases versus controls who added a statin (difference=6.22%, p<0.05). Among the patient intervention component there were 12.3% and 8.6% cases versus controls who added a statin (difference 3.84%, p<0.05). Significant positive predictors of adding a statin include presence of cardiovascular disease, females, and higher comorbidities. Conclusion: Educational letter-based programs that are directed to physicians and patients are effective in promoting the use of statin therapy among diabetics.