Objective: Migraine, affecting 11% of the US population, is a vastly under diagnosed and underreported disease. Migraine can impact patients' work and studies, family relationships, social relationships and emotional well-being thus undermining quality of life. A review of quality of life instruments in migraine is summarized. Methods: Review of literature using Pubmed with combinations of search terms ‘migraine', 'quality of life', ‘questionnaire' was conducted. Articles were selected based on measurement of disability or quality of life in migraine. Fields extracted from articles for each instrument and on the basis of which analyzed included name and type of instrument, applicable age group, types of respondent, means of administration, items and domains, scaling, item selection and psychometric properties. Pediatric versions of questionnaires were not included in the study. Results: Of the instruments that were identified 3 were generic, 11 were migraine specific questionnaires for quality of life in migraine and 3 were migraine specific questionnaires testing patients' response to therapy. The average age of participants ranged from 36.5 years to 44 years. The items varied in range from 5 to 45 with domains ranging from 2 to 8. Quality of life was assessed by most instruments on the basis of physical disability such as the MIDAS and MIGSEV. However, instruments such as HDI and MSQOL have also included emotional disability in the assessment of quality of life. Cronbach's alpha of reported ranged from 0.77 to 0.9 and one or more validities was established in all instruments. Conclusion: Although all instruments claim to assess the quality of life of patients, not all include physical and emotional functions. The MSQ seems most complete in this aspect, considering the psychometric properties that are reported. In the future, instruments assessing response to therapy should include domains measuring emotional and physical disability to improve treatment schedules.