Objective: Chronic hepatitis C (CHC) is a life threatening disease with long term consequences although the early stage is considered ‘asymptomatic'. This study is to explore if higher resource utilization occurs for early-stage CHC patients (case) than non-CHC (control) subjects. Methods: A large longitudinal database, Health Improvement Network (THIN), was retrospectively analyzed. THIN contains medical records of over 2.2 million anonymous subjects representing UK population. Cases were defined with confirmed CHC diagnosis and no records related to fibrosis, cirrhosis, decompensated liver conditions, and liver transplantation. Propensity matching techniques were applied to identify controls who did not have CHC diagnosis but matched cases on CHC propensity based on age, weight, height, gender, smoking, and alcohol consumption. Resource utilization patterns based on the retrieved medical records were compared between two groups. Odds ratios (OR) and 95% confidence intervals (CI) were derived from logistic regression models controlling for follow-up duration; 95%CI excluding 1 is considered statistically significant. Results: The case group (N=1576) and the control group (N=5234) matched on all demographic factors. On average, case subjects were 45.0 (13.3) years old, 64.7% male, and were followed 4.21 years after CHC diagnosis in the database. Compared to the control, case subjects had 69% greater chance of having specialist referral/visits (OR: 1.69, 95%CI: 1.50-1.91), and 70% higher probability of hospitalization and emergency/accident visits (OR: 1.70; 1.46-1.98). Case subjects also had 90% more chance using additional tests/procedures (OR: 1.90; 1.68-2.15) with key drivers from endoscopy (OR: 3.56; 2.39-5.31), MRI (OR: 1.93; 1.23-3.03), and ultrasound (OR: 1.73; 1.17-2.57). Among CHC subjects, age 50-60 (N=265) and >60 groups (N=180) recorded significantly more healthcare resource uses than age<40 (N=545) and 40-50 (N=586) group. Conclusion: CHC subjects consumed more health care resources than matching non-CHC controls in UK even at the early stage of this serious liver disease.