Objective: To examine whether physicians' practice specialties are associated with the types of anti-diabetic treatments for patients with type 2 diabetes (T2D). Methods: A retrospective study design was used based. All T2D patients' (N=1,819,323) medication histories in a 12 month period were examined and classified into 9 treatment types (no anti-diabetic medication, oral anti-diabetic medication (OAD), basal insulin only, prandial insulin only, basal insulin with OAD, prandial insulin with OAD, basal/prandial insulin, basal/prandial insulin(including premixed insulins) with OAD, other insulin regimens). Physicians practice specialties were classified into five categories (family medicine, internal medicine, other primary care specialists, endocrinologists, other specialties). A two-way contingency table was created with Chi-square test and Fisher's exact test to examine the possible association between physicians' practice specialty and the types of anti-diabetic treatments they prescribed. Results: Both the Chi-square test and the Fisher's exact test had p<0.0001, indicating that physicians' practice specialty and their patients' anti-diabetic treatment choices were statistically significantly associated. The contingency table suggests that the percent of patients receiving no anti-diabetic medications varied across specialties from 36.0% in patients who visited an endocrinologist to 49% and 52% in patients who visited a family medicine physician or internist, respectively. The percent of patients receiving OAD only varied across specialties from 33.1% in patients who visited an endocrinologist to 46.8% in patients who saw a family medicine physician, and 43.6% in patients under the care of an internist. And the percent of patients receiving insulin as part of their regimen varied across specialties from 4.12% in patients who visited a family medicine physician to 12.3% in patients who visited an endocrinologist. Conclusion: Physicians' practice specialty is strongly associated with anti-diabetic medications prescribed for patients with T2D. Further research to examine outcomes differences across physician specialties is needed.