Objective: Migraines afflict about 30 million people in the United States. Determining how migraineurs differ from non-migraneurs from the viewpoint of health resource utilization may provide insights that could lead to more effective care strategies. The objective of this study is to compare resource utilization between migraineurs and non-migraineurs. Methods: Caremark administrative pharmacy and medical claims data were analyzed in this study over a one year period. Individuals with at least one migraine medical claim (ICD-9 of 346.xx) and one triptan/ergot claim were used to identify participants with Migraine. Propensity score matching was used to sample participants without migraine (controls) matched for age, gender, and number of co-morbidities. Outcomes included number of visits and expenditures associated with office visits (MD), emergency room visits (ER), hospitalizations (HOS) using medical claims data, and prescription costs (Rx) using pharmacy claims data. Analysis of covariance was used to determine differences in health care use and expenditures, adjusting for age, gender, and number of co-morbidities. Results: There were 13,796 participants in the analysis. Baseline characteristics (age, gender, and number of co-morbidities) were comparable in the two groups after matching. Eighty percent of migraine participants identified were female. Analyses involving the complete models showed that migraineurs incurred significantly higher expenditure than non-migraineurs. After adjusting for age, sex and number of co-morbidities, migraineurs had significantly more ER visits per year (0.7 vs. 0.2, p<0.0001). Annual ER, HOS, and Total expenditures were significantly higher in the Migraine cohort (ER: $480 vs. $125, p<0.0001 and HOS: $980 vs. $588, p<0.00001 and Total: $4233 vs. $2004, p<0.0001) Conclusion: Migraine patients utilize more health care resources and incur higher healthcare expenditures. Study findings highlight the benefits to be realized by managing individuals with migraine.