Objective: To evaluate the cost and outcomes of a weight control program in a regional hospital at southern Taiwan. Methods: A total of 249 subjects with BMI over 24 were recruited from August 2003 to June 2004. Monthly courses providing nutritional consultation and exercise instructions for fitness were offered in three sessions per week with class size less than 25 members. Content of the course includes Physical Fitness exercise coaching, healthy diet and prescription of medication for weight control, and consultation for behavior change. Statistic analysis of data was performed with SAS software. Results: The mean age of the 249 subjects is 38.39(±12.36) years old, with 202(81.1%) female and 47(19.9%) male. The mean of BMI is 29.98(±5.10) kg/m2, mean of body fat percentage is 38.88(±7.54). Cost for the weight control clinic service includes pharmaceutical, special formula of diet, education for healthy eating, aerobic exercise coaching, personnel and administrative expense. Analysis revealed the total cost for each person-visit of a subject is 4426 NT dollars, with 5016 NT dollars per visit for subjects accepting additional fitness training. The weight decrease in average is 4.52+7.52 kg, and the length of follow up in average is 68.97+54.36 day. In total there is 610.3 kg of weight reduction during the period of the project and the average cost for each kg weight reduction is 2212±516 NT dollars. Statistic analysis with Mixed Model revealed that after adjusted by gender and age, the BMI of subjects will decrease by an estimate of 0.03757 with the increase of each day. Conclusion: The strategy of combining medication prescription, diet consultation and exercise coaching to reduce body weight in the beginning of the course is an effective enforcement to motivate the subject to establish the habit of regular exercise.