Objective: To examine the relationship between distance visual acuity (DVA) and self-reported vision-related quality of life in NV-AMD subjects. Methods: Baseline data from 113 subjects completing 30 weeks in the PERSPECTIVES study, a multi-center, multi-national 102-week clinical trial for the treatment of NV-AMD, were reviewed. Vision function of the better-seeing eye based on DVA (ETDRS letters at 2m), near vision (Bailey-Lovie logMAR scores at 25cm), reading speed (words/minute at 25cm), and contrast sensitivity (Pelli-Robson logMAR score at 1m) were all measured. Vision-related quality of life (VR-QOL) was collected using the National Eye Institute Visual Functioning Questionnaire 25 (NEI-VFQ). Correlations were tested using Pearson's R, a=0.05. Results: Subject mean age was 74.0 years (±8.0); 67 (59%) were female; and 109 (97%) were white. DVA was significantly correlated with the three clinical measures of vision function (p<0.001). DVA was also correlated with the NEI-VFQ Distance Vision domain (p=0.011) but not significantly associated with the Near Vision domain (p=0.057). With the exception of driving and color vision (p=0.426 and p=0.135), the remaining domain scores were significantly correlated with the DVA measure (range p=0.029 to p=0.001). Conclusion: Some differences in self-reported VR-QOL can be explained by DVA, while other effects on vision functioning are less clear. Therefore, it may be preferable to use more than one measure of vision function when assessing treatment effects.