Objective: To study preventive technologies economic efficiency for patients with cardiovascular diseases in Russia. Methods: The study consisted of two parts. The first part involved 303 hypertensive patients without serious s complications. The second part involved 100 patients with coronary heart disease (CHD). In both substudies, patients were randomized to treatment and control groups. Patients of the treatment group participated in a structured education program for hypertensive patients or for patients with CHD, and patients of control group were in routine clinical practice. All patients were observed during 12 months. Economic efficiency in both cases was evaluated on the basis of “cost of illness” and “cost-effectiveness” analysis. Results: In hypertensive patients we received the following results. The cost-efficiency ratio for decreasing blood pressure on 1% was $216.6 in the treatment group and $1179 in the control group. The results of patients' education in CHD patient were the following: The cost-efficiency ratio for decreasing angina attacks frequency on 1% was S974 in treatment group and 2838$ in control group. The cost-efficiency ratio for decreasing cholesterol on 1% was $2857 in the treatment group and S4365 in the control group. The cost-efficiency ratio for decreasing blood pressure on 1% was $1606 in the treatment group and $9316 in the control group. Conclusion: Educational preventive technologies for patients with cardiovascular diseases are cost-effective over a one-year period.