Objective: Vision disorders have a negative impact on quality of life (QoL). While the impairment of QoL in central-vision loss (CVL) disorders, e.g. age-related macular degeneration (ARMD), is widely acknowledged, the QoL impact of peripheral-vision loss (PVL) disorders, e.g. glaucoma, is less well-known. We performed a systematic literature search to assess the effect on QoL of PVL versus CVL. Methods: We searched MEDLINE, BIOSIS, EMBASE, and Cochrane databases. Results: A total of 87 publications were identified (some reported >1 instrument): Short-Form Health Survey (SF)-36 was used in 23 (PVL=2; CVL=21), SF-12 in 6 (PVL=1; CVL=5), National Eye Institute Visual Function Questionnaire (NEI-VFQ)-51 in 11 (PVL=4; CVL=7), NEI-VFQ-39 in 9 (PVL=1; CVL=8), NEI-VFQ-25 in 36 (PVL=11; CVL=25), EuroQol EQ-5D in 3 (PVL=1; CVL=2), Visual Function-14 (VF-14) in 20 (PVL=1; CVL=19), Sickness Impact Profile (SIP) in 4 (PVL=2 [1 study]; CVL=2), and Impact of Vision Impairment (IVI) in 1 (including 3 diseases: glaucoma, retinopathy [PVL] and ARMD [CVL]). By SF-36, vitality was impacted most in PVL. By SF-36 and SF-12, generally, mental health domains were affected more in PVL than CVL; physical domains were affected most in CVL. Mental aspects of QoL were affected more in PVL than CVL in all NEI-VFQ studies; ARMD and glaucoma impacted different domains. QoL was generally lower in glaucoma than ARMD, although results varied amongst studies. By EQ-5D, QoL in PVL and CVL were similarly affected. By VF-14 and SIP, CVL impacted QoL slightly more than PVL. By SIP, psychosocial and physical domains were affected equally in PVL. In the IVI study, PVL affected QoL slightly more than CVL (except glaucoma on the social scale). Conclusion: Results showed in general, PVL and CVL disorders have a significant impact on QoL. More QoL research towards better understanding patients' concerns with their PVL and CVL disorders are warranted.