Objective: To compare the health-related quality of life (HRQOL) between patients undergoing continuous ambulatory peritoneal dialysis (CAPD), automated peritoneal dialysis (APD) and haemodialysis (HD) in the “IMSS” (Mexican Institute of Social Security) in Guadalajara. Methods: Transverse analytic study included 131 patients, in peritoneal dialysis, = 18 years, any gender, or time under dialysis. Patients with acute technique-related complications, in terminal phase of illness, or with physical or mental disability were excluded. An interview, clinical history and detailed physical examination were carried out. Using the Kidney Disease Quality of Life Short Form (KDQOL-SFTM), we measured HRQOL.Analysis of variance was used to examine differences. Results: Patients were studied (50 undergoing CAPD, 34 APD and 47 HD). The average age was 46.2 ± 18.3 years, 53% were females, and 49% were males. The time in CAPD was 23.4 ± 17.2, APD 23.9 ± 14.2 and HD 37 ± 34 months. Physical functioning (37±28), pain (69±25), emotional well-being (52±26), social function (57±30), and energy/fatigue (37±27) were significantly lower scores in CAPD in comparison with APD (65±31, 93±12, 75±28, 91±15, 60±28) and HD (57±29, 82±17, 69±23, 80±21, 53±28). The Effects of Kidney Disease (86±15) and Burden of Kidney Disease (58±36) subscales were lower in APD in comparison with CAPD (76±16 and 24±29, respectively); no differences between CAPD and HD. The physical component summary was significantly higher in APD (58±22) in comparison with CAPD (46±15) and HD (34±15). Mental component summary was less in CAPD (36±15) in comparison with APD (60±22) and HD (46±15). Conclusion: The HRQL in patients undergoing CAPD was less in comparison with patients with APD and HD. The physical dimension was higher in patients with APD in comparison with CAPD and HD, whereas the mental dimension was less in the CAPD group. There was no significant difference between the APD and HD groups.