Objective: To study clinical determinants of satisfaction and health-related quality of life (HRQoL) in patients with cardiac disease and dyslipidemia. Methods: A prospective, cross sectional study was conducted using a questionnaire. The questionnaire containing SF-12v1 general health survey (range 0-100), the MacNew Heart disease health-related quality of life instrument (range 1-7), and questions regarding satisfaction with care (range 1-7) and demographics were administered to randomly selected patients seeking care in a secondary prevention lipid clinic. A unique de-identified patient code was matched with medical charts to obtain clinical information. Descriptive analyses and stepwise regression analyses were conducted to assess study objectives. Results: A total of 124 participants (65.7% male) completed the survey; response rate was 72.9%. Physical (PCS) and mental (MCS) component summary scores of the SF-12v1 scale were 37.3 (± 9.2) and 49.1 (±9.7), respectively. The scores of the MacNew scale domains were physical (5.2±1.3), emotional (5.2±0.9), social (5.5±1.3), and global (5.2±1.0), respectively. In general, the participants in the study were satisfied with the care provided (4.28±0.62). Multivariate analysis indicated that LDL levels (ß=-0.37) and triglycerides levels (ß=-0.26) significantly (p<0.05) predicted the MCS scores, while drug type (ß=-0.51) and gender (ß=-0.32) significantly (p<0.05) predicted PCS scores. With respect to the MacNew scale, LDL levels (ß=-0.29), triglycerides (ß=-0.22), and diastolic blood pressure (ß=0.28) significantly (p<0.05) predicted emotional scores, while drug type (ß=-0.26) significantly (p<0.05) predicted physical scores. Further, LDL goals achieved (ß=0.22) and BMI (ß=-0.27) significantly (p<0.05) predicted satisfaction with care. Conclusion: Results suggest that LDL levels, triglycerides levels, and drug type used significantly affected HRQoL as measured by both scales and LDL goals achieved BMI significantly affected satisfaction with care. This information is valuable for future interventional studies aiming to improve HRQoL and satisfaction with care provided after cardiac disease and may aid physicians' decisions while providing care.