ANGINA FOLLOWING REVASCULARIZATION - FREQUENCY, PATIENT CHARACTERISTICS AND TIMING

Author(s)

Judith Kempf, PhD, Exec. Dir. Outcomes1, Sharashchandra Shetty, PhD, Assoc. Director2, Michael Nelson, PharmD, Vice President2, Erin Buysman, MS, Senior Researcher21CV Therapeutics, Palo Alto, CA, USA; 2 i3 Innovus, Eden Prairie, MN, USA

Objective: Angina is relieved by CABG, PCI and stenting procedures but reoccurs over time in a percentage of patients. Little is known about the frequency of recurrent angina following percutaneous and surgical procedures, the characteristics which put a patient at risk for recurrent angina and the timing of angina recurrence. Methods: Patients enrolled in a large national managed care plan with a claim for a CABG, PCI or stent from January 1, 2003 to Decemeber 31, 2004 were selected if they were 35 or older, and enrolled one year prior and one year following their procedure. Patients were followed for one year after their index procedure for medication use, angina diagnosis by ICD-9 code and additional revascularization procedures. Results: Following selection criteria 18,240 patients were eligible for analysis. The average age was 59 years, with 25% age 65 years and older. Most patients were male (78%). Of the 18,240 patients, 46% (8420) experienced angina (identified by angina diagnosis and/or two or more nitrate prescriptions) within a year following their index procedure. Of those patients experiencing angina, approximately a third (30%/2904) had another revascularization procedure following the angina diagnosis. The average time from initial procedure to second procedure, after angina diagnosis, was 73 days, although there is a wide range among patients (SD=103 days). Risk factors for having angina following a revascularization procedure were younger age, female gender and having a PCI without a stent. Conclusion: Angina reoccurs in a considerable percentage of patients in the year following a percutaneous or surgical coronary procedure. A third of patients experiencing angina have a second procedure after experiencing recurrent angina.

Conference/Value in Health Info

2008-05, ISPOR 2008, Toronto, Ontario, Canada

Value in Health, Vol. 11, No. 3 (May/June 2008)

Code

PCV13

Topic

Epidemiology & Public Health

Disease

Cardiovascular Disorders

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