OBJECTIVES:  To analyze, for the first time in a large Spanish population of heart failure patients, quality of life according to NYHA class II, III or IV using generic and specific quality of life questionnaires. METHODS: A descriptive analysis of a multicenter, prospective observational study was performed. Patients who met inclusion criteria were followed-up for a period of 12 months, with 3 visits programmed at baseline, 6 months and 12 months. A total of 9 Spanish hospitals were involved in the study. Questionnaires used to measure quality of life were: EQ-5D (generic questionnaire), Minessotta living with heart failure- MLWHF (specific questionnaire) and Barthel Index (index of independence). RESULTS: A total of 450 patients were included, 76% men, mean age was 62.6 years. 66.1% were in NYHA class II, 32.7% NYHA class III and 1.1% NYHA class IV. Prevalence of ischemic cardiopathy was 33.5%. 35% of patients had an implantable device (ICD, RCT or pacemaker). Significant differences were observed in Barthel Index’s scores depending on class: class I 97.6 ± 6.7 vs. Class III-IV 91.8 ± 14.6. Related to EQ-5D tariffs, individuals in class II had a mean value of 0.8407 ± 0.1887 (out of 1), and mean VAS value of 60.6 ± 17.39 (out of 100). Individuals in NYHA class III or IV had a mean score of 0.6624 ± 0.2848, and mean VAS value of 51.93 ± 17.15 (out of 100). In a MLWHF questionnaire analyses, patients in NYHA class II showed a mean score of 32.52 ± 20.69 while patient in NYHA class III-IV showed a mean score of 50.44 ± 18.23. CONCLUSIONS: Our findings showed the results from the three questionnaires were generally consistent with each other and values reported from other countries in the literature.