OBJECTIVES: The UK’s National Institute for Health and Clinical Excellence (NICE) and the Jordan office of the Medicines Transparency Alliance embarked on a pilot project to design an evidence-based guideline for cost-effective pharmacological treatment of essential hypertension in Jordan. The project’s objectives were to directly address a major health problem for Jordan by producing a guideline; and to delineate the strengths and weaknesses of Jordan’s health care process to allow similar future efforts to be planned more efficiently. METHODS: The pilot spanned a period of approximately 8 months. Activities were overseen by local technical and guideline development teams, as well as experts from NICE. NICE’s hypertension guidelines and economic model were used as a starting point. Parameters in the economic model were adjusted according to input and feedback from local experts with regards to Jordanian physician and patient practices, resource costs, and quality of life estimates. The results of the economic model were integrated with the updated available clinical trial literature. RESULTS: The outputs of the economic model were used to inform recommendations, in the form of a clinical algorithm. A report of the process and the strengths and weaknesses observed was developed, and recommendations for improvements made. CONCLUSIONS: The pilot represented the start of what is intended to be a health care process change for the country of Jordan. Issues emerged which can inform strategies to ensure a more cohesive and comprehensive health care approach to the cost-effective use of appropriate drugs in managing chronic disease. The project highlighted how countries with relevant experience in evidence-informed policy making in health care can assist others in strengthening their decision-making systems.